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Carcinomas contain an MMP-resistant isoform of type I collagen exerting selective support to invasion

Collagen fibers affect metastasis in two opposing ways, by supporting invasive cells but also generating a barrier to invasion. We hypothesized that these functions might be performed by different isoforms of type I collagen. Carcinomas are reported to contain α1(I)(3) homotrimers, a type I collagen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Makareeva, Elena, Han, Sejin, Vera, Juan Carlos, Sackett, Dan L., Holmbeck, Kenn, Phillips, Charlotte L., Visse, Robert, Nagase, Hideaki, Leikin, Sergey
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880213/
https://ncbi.nlm.nih.gov/pubmed/20460529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4057
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