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Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro

CHK1 is an important regulator of the cell cycle and DNA damage response, and its altered expression has been identified in various tumors. Chk1 inhibitors are currently being evaluated as monotherapy and as potentiators of chemotherapy in clinical settings. However, to our knowledge, no previous st...

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Détails bibliographiques
Publié dans:Cancer Med
Auteurs principaux: Wang, Zhihui, Førsund, Mette S., Trope, Claes G., Nesland, Jahn M., Holm, Ruth, Slipicevic, Ana
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089182/
https://ncbi.nlm.nih.gov/pubmed/29963769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1638
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