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Improving small molecule virtual screening strategies for the next generation of therapeutics

The new generation of post-genomic targets, such as protein-protein interactions (PPIs), often require new chemotypes not well represented in current compound libraries. This is one reason for why traditional high throughput screening (HTS) approaches are not more successful in delivering medicinal...

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Détails bibliographiques
Publié dans:Curr Opin Chem Biol
Auteurs principaux: Wingert, Bentley M., Camacho, Carlos J.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089075/
https://ncbi.nlm.nih.gov/pubmed/29920436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2018.06.006
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