ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2

Apolipoprotein L1 (ApoL1) genetic variants are strongly associated with kidney diseases. We investigated the role of ApoL1 variants in monocyte differentiation and eicosanoid production in macrophages, as activated tissue macrophages in kidney might contribute to kidney injury. In human monocyte THP...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Lee, Hewang, Roshanravan, Hila, Wang, Ying, Okamoto, Koji, Ryu, Junghwa, Shrivastav, Shashi, Qu, Peng, Kopp, Jeffrey B.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087794/
https://ncbi.nlm.nih.gov/pubmed/29357411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00254.2017
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