Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8

Following the discovery of (R)-roscovitine’s beneficial effects in three polycystic kidney disease (PKD) mouse models, cyclin-dependent kinases (CDKs) inhibitors have been investigated as potential treatments. We have used various affinity chromatography approaches to identify the molecular targets...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Billot, Katy, Coquil, Charlène, Villiers, Benoit, Josselin-Foll, Béatrice, Desban, Nathalie, Delehouzé, Claire, Oumata, Nassima, Le Meur, Yannick, Boletta, Alessandra, Weimbs, Thomas, Grosch, Melanie, Witzgall, Ralph, Saunier, Sophie, Fischer, Evelyne, Pontoglio, Marco, Fautrel, Alain, Mrug, Michal, Wallace, Darren, Tran, Pamela V., Trudel, Marie, Bukanov, Nikolay, Ibraghimov-Beskrovnaya, Oxana, Meijer, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087785/
https://ncbi.nlm.nih.gov/pubmed/29537311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00489.2017
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