Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling

One of the crucial cardiac signaling pathways is cAMP-mediated PKA signal transduction, which is regulated by a family of scaffolding proteins, i.e., A-kinase anchoring proteins (AKAPs). Muscle-specific AKAP (mAKAP) partly regulates cardiac cAMP/PKA signaling by binding to PKA and phosphodiesterase...

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Publicado en:Am J Physiol Heart Circ Physiol
Autores principales: Suryavanshi, Santosh V., Jadhav, Shweta M., Anderson, Kody L., Katsonis, Panagiotis, Lichtarge, Olivier, McConnell, Bradley K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087776/
https://ncbi.nlm.nih.gov/pubmed/29600899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00034.2018
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