Mitochondrial inner membrane protein (mitofilin) knockdown induces cell death by apoptosis via an AIF-PARP-dependent mechanism and cell cycle arrest

Mitofilin is an inner membrane protein that has been defined as a mitochondria-shaping protein in controlling and maintaining mitochondrial cristae structure and remodeling. We determined the role of mitofilin in cell survival by investigating the mechanism underlying mitofilin knockdown-induced cel...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Madungwe, Ngonidzashe B., Feng, Yansheng, Lie, Mihaela, Tombo, Nathalie, Liu, Li, Kaya, Ferdinand, Bopassa, Jean C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087732/
https://ncbi.nlm.nih.gov/pubmed/29489384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00230.2017
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