Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

Huntington's disease (HD) is a dominant neurodegenerative disease caused by polyglutamine (polyQ) expansion in the protein huntingtin (htt). HD pathogenesis appears to involve the production of mutated N-terminal htt, cytoplasmic and nuclear aggregation of htt, and abnormal activity of htt inte...

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Bibliografiske detaljer
Main Authors: Parker, J. Alex, Connolly, John B., Wellington, Cheryll, Hayden, Michael, Dausset, Jean, Neri, Christian
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC60868/
https://ncbi.nlm.nih.gov/pubmed/11687635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231476398
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