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Mettl1/Wdr4-mediated m(7)G tRNA methylome is required for normal mRNA translation and embryonic stem cell self-renewal and differentiation
tRNAs are subject to numerous modifications including methylation. Mutations in the human N(7)-methylguanosine (m(7)G) methyltransferase complex METTL1/WDR4 cause primordial dwarfism and brain malformation yet the molecular and cellular function in mammals is not well understood. We developed m(7)G...
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| Udgivet i: | Mol Cell |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6086580/ https://ncbi.nlm.nih.gov/pubmed/29983320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.001 |
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