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Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span

Despite limited regenerative capacity as we age, cardiomyocytes maintain their function in part through compensatory mechanisms, e.g., Vinculin reinforcement of intercalated discs in aged organisms. This mechanism, which is conserved from flies to non-human primates, creates a more crystalline sarco...

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Detalhes bibliográficos
Publicado no:APL Bioeng
Main Authors: Sessions, Ayla O., Min, Peter, Cordes, Thekla, Weickert, Barry J., Divakaruni, Ajit S., Murphy, Anne N., Metallo, Christian M., Engler, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: AIP Publishing LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086353/
https://ncbi.nlm.nih.gov/pubmed/30105314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.5019592
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