Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span of Drosophila melanogaster

The redox state of tissues tends to become progressively more prooxidizing during the aging process. The hypothesis tested in this study was that enhancement of reductive capacity by overexpression of glucose-6-phosphate dehydrogenase (G6PD), a key enzyme for NADPH biosynthesis, could protect agains...

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Bibliografiske detaljer
Main Authors: Legan, Susan K., Rebrin, Igor, Mockett, Robin J., Radyuk, Svetlana N., Klichko, Vladimir I., Sohal, Rajindar S., Orr, William C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Metabolism and Bioenergetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583299/
https://ncbi.nlm.nih.gov/pubmed/18809674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805832200
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