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Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines

BACKGROUND: Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an enzyme required for de novo purine biosynthesis, is associated with and involved in tumorigenesis. This study aimed to evaluate the role of PAICS in human breast cancer, which...

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Detalhes bibliográficos
Publicado no:Biol Res
Main Authors: Meng, Minjun, Chen, Yanling, Jia, Jianbo, Li, Lianghui, Yang, Sumei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086025/
https://ncbi.nlm.nih.gov/pubmed/30097015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40659-018-0172-9
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