Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro

Objective: Geniposide (GE) is a major component in the fruit of Gardenia jasminoides Ellis. Oxidative stress, endoplasmic reticulum (ER) stress, and canonical Smad3 pathway are implicated in the pathogenesis of cardiac fibrosis. We aim to investigate the protective roles of GE in isoproterenol (ISO)...

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Publicado en:Front Pharmacol
Main Authors: Li, Ning, Zhou, Heng, Ma, Zhen-Guo, Zhu, Jin-Xiu, Liu, Chen, Song, Peng, Kong, Chun-Yan, Wu, Hai-Ming, Deng, Wei, Tang, Qi-Zhu
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086014/
https://ncbi.nlm.nih.gov/pubmed/30123131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00854
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