Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro

Objective: Geniposide (GE) is a major component in the fruit of Gardenia jasminoides Ellis. Oxidative stress, endoplasmic reticulum (ER) stress, and canonical Smad3 pathway are implicated in the pathogenesis of cardiac fibrosis. We aim to investigate the protective roles of GE in isoproterenol (ISO)...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Li, Ning, Zhou, Heng, Ma, Zhen-Guo, Zhu, Jin-Xiu, Liu, Chen, Song, Peng, Kong, Chun-Yan, Wu, Hai-Ming, Deng, Wei, Tang, Qi-Zhu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086014/
https://ncbi.nlm.nih.gov/pubmed/30123131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00854
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