Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance

SUMMARY: Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for immune responses to pathogen replication, cellular stress, and cancer. Existing structures of the mouse cGAS-DNA complex provide a model for enzyme activation, but do not explain why human cGAS exhibits severely red...

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Publicado en:Cell
Autores principales: Zhou, Wen, Whiteley, Aaron T., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Nowak, Radostaw P., Fischer, Eric S., Gray, Nathanael S., Mekalanos, John J., Kranzusch, Philip J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084792/
https://ncbi.nlm.nih.gov/pubmed/30007416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.06.026
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