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VprBP/DCAF1 Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation
The assembly of immunoglobulin genes in developing B lymphocytes by V(D)J recombination is initiated by the RAG1-RAG2 endonuclease complex. We previously identified an interaction between RAG1 and VprBP/DCAF1, a substrate receptor for the Cullin 4-RING E3 ubiquitin ligase (CRL4). We report here that...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6084458/ https://ncbi.nlm.nih.gov/pubmed/29925675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800054 |
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