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VprBP is required for efficient editing and selection of Igκ(+) B cells, but is dispensable for Igλ(+) and marginal zone B cell maturation and selection
B cell development past the pro-B cell stage in mice requires the Cul4-DDB1-Roc1 E3 ubiquitin ligase substrate recognition subunit VprBP. Enforced Bcl2 expression overcomes defects in distal V(H)-DJ(H) and secondary Vκ-Jκ rearrangement associated with VprBP-insufficiency in B cells, and substantiall...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530030/ https://ncbi.nlm.nih.gov/pubmed/26150531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500952 |
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