VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1

The oncogenic transcription factor FoxM1 plays a vital role in cell cycle progression, is activated in numerous human malignancies, and is linked to chromosome instability. We characterize here a cullin 4-based E3 ubiquitin ligase and its substrate receptor, VprBP/DCAF1 (CRL4(VprBP)), which we show...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Wang, Xianxi, Arceci, Anthony, Bird, Kelly, Mills, Christine A., Choudhury, Rajarshi, Kernan, Jennifer L., Zhou, Chunxiao, Bae-Jump, Victoria, Bowers, Albert, Emanuele, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472828/
https://ncbi.nlm.nih.gov/pubmed/28416635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00609-16
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