22‐S‐Hydroxycholesterol protects against ethanol‐induced liver injury by blocking the auto/paracrine activation of MCP‐1 mediated by LXRα

Chronic ethanol consumption causes hepatic steatosis and inflammation, which are associated with liver hypoxia. Monocyte chemoattractant protein‐1 (MCP‐1) is a hypoxia response factor that determines recruitment and activation of monocytes to the site of tissue injury. The level of MCP‐1 is elevated...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Pathol
Main Authors: Na, Tae‐Young, Han, Young‐Hyun, Ka, Na‐Lee, Park, Han‐Su, Kang, Yun Pyo, Kwon, Sung Won, Lee, Byung‐Hoon, Lee, Mi‐Ock
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084351/
https://ncbi.nlm.nih.gov/pubmed/25557254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4494
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