An insight into tetrahydro-β-carboline–tetrazole hybrids: synthesis and bioevaluation as potent antileishmanial agents

A series of 2,3,4,9-tetrahydro-β-carboline tetrazole derivatives (14a–u) have been synthesized utilizing the Ugi multicomponent reaction and were identified as potential antileishmanial chemotypes. Most of the screened derivatives exhibited significant in vitro activity against the promastigote (IC(...

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Библиографические подробности
Опубликовано в: :Medchemcomm
Главные авторы: Purohit, Pooja, Pandey, Anand Kumar, Singh, Deepti, Chouhan, Pradeep Singh, Ramalingam, Karthik, Shukla, Mahendra, Goyal, Neena, Lal, Jawahar, Chauhan, Prem M. S.
Формат: Artigo
Язык:Inglês
Опубликовано: Royal Society of Chemistry 2017
Предметы:
Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084189/
https://ncbi.nlm.nih.gov/pubmed/30108893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00125h
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