Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice

BACKGROUND: Podocyte dedifferentiation and mesangial cell (MC) activation play an important role in many glomerular diseases associated with fibrosis. MicroRNA-21 (miR-21) is closely linked to renal fibrosis, but it is unknown whether and how miR-21 promotes podocyte dedifferentiation and MC activat...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wang, Xiaolei, Gao, Yanbin, Tian, Nianxiu, Zou, Dawei, Shi, Yimin, Zhang, Nan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084069/
https://ncbi.nlm.nih.gov/pubmed/30122901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S170840
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