Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit

AIM: Mesangial cell (MC) activation plays an important role in many glomerular diseases associated with renal fibrosis, including diabetic kidney disease (DKD). The aim of this study was to determine whether Astragaloside IV (AS-IV) modulated MC activation in DKD via autophagy by specifically regula...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wang, Xiaolei, Gao, Yanbin, Tian, Nianxiu, Zhu, Zhiyao, Wang, Tao, Xu, Jiayi, Wu, Bingjie, Zhang, Nan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140761/
https://ncbi.nlm.nih.gov/pubmed/30254426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S174058
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