The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris—Analysis of Four Different Ethnic Cohorts

IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with...

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Udgivet i:Front Immunol
Main Authors: Recke, Andreas, Konitzer, Sarah, Lemcke, Susanne, Freitag, Miriam, Sommer, Nele Maxi, Abdelhady, Mohammad, Amoli, Mahsa M., Benoit, Sandrine, El-Chennawy, Farha, Eldarouti, Mohammad, Eming, Rüdiger, Gläser, Regine, Günther, Claudia, Hadaschik, Eva, Homey, Bernhard, Lieb, Wolfgang, Peitsch, Wiebke K., Pföhler, Claudia, Robati, Reza M., Saeedi, Marjan, Sárdy, Miklós, Sticherling, Michael, Uzun, Soner, Worm, Margitta, Zillikens, Detlef, Ibrahim, Saleh, Vidarsson, Gestur, Schmidt, Enno
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082936/
https://ncbi.nlm.nih.gov/pubmed/30116249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01788
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