BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity

Base editor (BE), containing a cytidine deaminase and catalytically defective Cas9, has been widely used to perform base editing. However, the narrow editing window of BE limits its utility. Here, we developed a new editing technology named as base editor for programming larger C to U (T) scope (BE-...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Jiang, Wen, Feng, Songjie, Huang, Shisheng, Yu, Wenxia, Li, Guanglei, Yang, Guang, Liu, Yajing, Zhang, Yu, Zhang, Lei, Hou, Yu, Chen, Jia, Chen, Jieping, Huang, Xingxu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082914/
https://ncbi.nlm.nih.gov/pubmed/29875396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0052-4
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