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Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
Epigenetic modifications such as aberrant DNA methylation reshape the gene expression repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) mouse model (Alb-R26(Met)) to explore the impact of DNA methylation on transcriptional switches associated with tumorigenesis...
Kaydedildi:
| Yayımlandı: | Nat Commun |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6082886/ https://ncbi.nlm.nih.gov/pubmed/30089774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05550-5 |
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