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Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
Epigenetic modifications such as aberrant DNA methylation reshape the gene expression repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) mouse model (Alb-R26(Met)) to explore the impact of DNA methylation on transcriptional switches associated with tumorigenesis...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6082886/ https://ncbi.nlm.nih.gov/pubmed/30089774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05550-5 |
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