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Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins

Organic chemistry allows for the modification and chemical preparation of protein analogues for various studies. The thiolate side chain of the Cys residue has been a key functionality in these ventures. In order to generate complex molecular targets, there is a particular need to incorporate orthog...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Jbara, Muhammad, Laps, Shay, Morgan, Michael, Kamnesky, Guy, Mann, Guy, Wolberger, Cynthia, Brik, Ashraf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082840/
https://ncbi.nlm.nih.gov/pubmed/30089783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05628-0
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