Histidine catabolism is a major determinant of methotrexate sensitivity

The chemotherapeutic drug methotrexate inhibits the enzyme DHFR (dihydrofolate reductase)(1), which generates tetrahydrofolate (THF), an essential cofactor in nucleotide synthesis(2). Depletion of THF causes cell death by suppressing DNA and RNA production(3). While methotrexate is widely used as an...

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Publicat a:Nature
Autors principals: Kanarek, Naama, Keys, Heather R., Cantor, Jason R., Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Freinkman, Elizaveta, Schweitzer, Lawrence D., Sabatini, David M.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082631/
https://ncbi.nlm.nih.gov/pubmed/29995852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0316-7
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