Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor

We have engineered the ecdysone-inducible mammalian expression system for general retroviral delivery to cultured mammalian cells. We inducibly expressed PTEN in the glioblastoma cell line, U87MG, lacking this gene. Because nearly all cells are recruited on induction, we find both up- and down-regul...

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Detaylı Bibliyografya
Asıl Yazarlar: Stolarov, Javor, Chang, Kenneth, Reiner, Andrew, Rodgers, Linda, Hannon, Gregory J., Wigler, Michael H., Mittal, Vivek
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC60821/
https://ncbi.nlm.nih.gov/pubmed/11687610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221450598
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