Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

Pulmonary alveolar proteinosis (PAP) is a syndrome of reduced GM-CSF-dependent, macrophage-mediated surfactant clearance, dysfunctional foamy alveolar macrophages, alveolar surfactant accumulation, and hypoxemic respiratory failure for which the pathogenetic mechanism is unknown. Here, we examine th...

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Udgivet i:Nat Commun
Main Authors: McCarthy, Cormac, Lee, Elinor, Bridges, James P., Sallese, Anthony, Suzuki, Takuji, Woods, Jason C., Bartholmai, Brian J., Wang, Tisha, Chalk, Claudia, Carey, Brenna C., Arumugam, Paritha, Shima, Kenjiro, Tarling, Elizabeth J., Trapnell, Bruce C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081448/
https://ncbi.nlm.nih.gov/pubmed/30087322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05491-z
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