Long-Term Safety and Efficacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra(−/−) Mice

Hereditary pulmonary alveolar proteinosis (PAP) is a genetic lung disease characterized by surfactant accumulation and respiratory failure arising from disruption of GM-CSF signaling. While mutations in either CSF2RA or CSF2RB (encoding GM-CSF receptor α or β chains, respectively) can cause PAP, α c...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Arumugam, Paritha, Suzuki, Takuji, Shima, Kenjiro, McCarthy, Cormac, Sallese, Anthony, Wessendarp, Matthew, Ma, Yan, Meyer, Johann, Black, Diane, Chalk, Claudia, Carey, Brenna, Lachmann, Nico, Moritz, Thomas, Trapnell, Bruce C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731469/
https://ncbi.nlm.nih.gov/pubmed/31326401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.06.010
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