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ATP activates bestrophin ion channels through direct interaction
Human Bestrophin1 (hBest1) is a Ca(2+)-activated Cl(−) channel in retinal pigment epithelium (RPE) essential for retina physiology, and its mutation results in retinal degenerative diseases that have no available treatments. Here, we discover that hBest1’s channel activity in human RPE is significan...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6081419/ https://ncbi.nlm.nih.gov/pubmed/30087350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05616-4 |
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