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Dual Ca(2+)-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations
Mutations of human BEST1, encoding a Ca(2+)-activated Cl(−) channel (hBest1), cause macular degenerative disorders. Best1 homolog structures reveal an evolutionarily conserved channel architecture highlighted by two landmark restrictions (named the “neck” and “aperture”, respectively) in the ion con...
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| Publicado no: | Commun Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591409/ https://ncbi.nlm.nih.gov/pubmed/31263784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0433-3 |
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