Mouse models of sporadic thyroid cancer derived from BRAF(V600E) alone or in combination with PTEN haploinsufficiency under physiologic TSH levels

The BRAF(V600E) mutation is the most prevalent driver mutation of sporadic papillary thyroid cancers (PTC). It was previously shown that prenatal or postnatal expression of BRAF(V600E) under elevated TSH levels induced thyroid cancers in several genetically engineered mouse models. In contrast, we f...

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Veröffentlicht in:PLoS One
Hauptverfasser: Shimamura, Mika, Shibusawa, Nobuyuki, Kurashige, Tomomi, Mussazhanova, Zhanna, Matsuzaki, Hiroki, Nakashima, Masahiro, Yamada, Masanobu, Nagayama, Yuji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080762/
https://ncbi.nlm.nih.gov/pubmed/30086162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201365
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