Mouse models of sporadic thyroid cancer derived from BRAF(V600E) alone or in combination with PTEN haploinsufficiency under physiologic TSH levels

The BRAF(V600E) mutation is the most prevalent driver mutation of sporadic papillary thyroid cancers (PTC). It was previously shown that prenatal or postnatal expression of BRAF(V600E) under elevated TSH levels induced thyroid cancers in several genetically engineered mouse models. In contrast, we f...

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Bibliographic Details
Published in:PLoS One
Main Authors: Shimamura, Mika, Shibusawa, Nobuyuki, Kurashige, Tomomi, Mussazhanova, Zhanna, Matsuzaki, Hiroki, Nakashima, Masahiro, Yamada, Masanobu, Nagayama, Yuji
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080762/
https://ncbi.nlm.nih.gov/pubmed/30086162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201365
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