Mouse models of sporadic thyroid cancer derived from BRAF(V600E) alone or in combination with PTEN haploinsufficiency under physiologic TSH levels

The BRAF(V600E) mutation is the most prevalent driver mutation of sporadic papillary thyroid cancers (PTC). It was previously shown that prenatal or postnatal expression of BRAF(V600E) under elevated TSH levels induced thyroid cancers in several genetically engineered mouse models. In contrast, we f...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Shimamura, Mika, Shibusawa, Nobuyuki, Kurashige, Tomomi, Mussazhanova, Zhanna, Matsuzaki, Hiroki, Nakashima, Masahiro, Yamada, Masanobu, Nagayama, Yuji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080762/
https://ncbi.nlm.nih.gov/pubmed/30086162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201365
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