Thyrotropin Signaling Confers More Aggressive Features with Higher Genomic Instability on BRAF(V600E)-Induced Thyroid Tumors in a Mouse Model

Background: The BRAF(V600E) mutation is the most common genetic alteration in papillary thyroid carcinomas (PTCs). Transgenic mice overexpressing BRAF(V600E) in their thyroids under control of the thyroglobulin promoter (Tg-BRAF2 mice) developed invasive PTCs with high penetrance. However, these mic...

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Bibliografiska uppgifter
Huvudupphovsmän: Orim, Florence, Bychkov, Andrey, Shimamura, Mika, Nakashima, Masahiro, Ito, Masahiro, Matsuse, Michiko, Kurashige, Tomomi, Suzuki, Keiji, Saenko, Vladimir, Nagayama, Yuji, Yamashita, Shunichi, Mitsutake, Norisato
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mary Ann Liebert, Inc. 2014
Ämnen:
Thyroid Cancer and Nodules
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949501/
https://ncbi.nlm.nih.gov/pubmed/23924149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2013.0038
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