A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations

OBJECTIVE: To introduce a disease prognosis framework enabled by a robust classification scheme derived from patient-specific transcriptomic response to stimulation. MATERIALS AND METHODS: Within an illustrative case study to predict asthma exacerbation, we designed a stimulation assay that reveals...

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Detalhes bibliográficos
Publicado no:J Am Med Inform Assoc
Main Authors: Gardeux, Vincent, Berghout, Joanne, Achour, Ikbel, Schissler, A Grant, Li, Qike, Kenost, Colleen, Li, Jianrong, Shang, Yuan, Bosco, Anthony, Saner, Donald, Halonen, Marilyn J, Jackson, Daniel J, Li, Haiquan, Martinez, Fernando D, Lussier, Yves A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Research and Applications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080688/
https://ncbi.nlm.nih.gov/pubmed/29016970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jamia/ocx069
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