kMEn: analyzing noisy and bidirectional transcriptional pathway responses in single subjects

MOTIVATION: Understanding dynamic, patient-level transcriptomic response to therapy is an important step forward for precision medicine. However, conventional transcriptome analysis aims to discover cohort-level change, lacking the capacity to unveil patient-specific response to therapy. To address...

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Veröffentlicht in:J Biomed Inform
Hauptverfasser: Li, Qike, Schissler, A. Grant, Gardeux, Vincent, Berghout, Joanne, Achour, Ikbel, Kenost, Colleen, Li, Haiquan, Zhang, Hao Helen, Lussier, Yves A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316373/
https://ncbi.nlm.nih.gov/pubmed/28007582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbi.2016.12.009
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