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Metal ion cooperativity in ribozyme cleavage of RNA

Combinations of chemical and genetic approaches were used to study the function of divalent metal ions in cleavage of RNA by the ribozyme RNase P RNA. We show that different divalent metal ions have differential effects on cleavage site recognition and rescue of cleavage activity by mixing divalent...

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Autors principals: Brännvall, Mathias, Kirsebom, Leif A.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC60804/
https://ncbi.nlm.nih.gov/pubmed/11606743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221456598
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