A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF‐α and HIF‐β subunits. Prolonged HIF expression is a key contributor to cellular transformation, tumorigenesis and metastasis. As...

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Bibliografische gegevens
Gepubliceerd in:EMBO Mol Med
Hoofdauteurs: Foxler, Daniel E, Bridge, Katherine S, Foster, John G, Grevitt, Paul, Curry, Sean, Shah, Kunal M, Davidson, Kathryn M, Nagano, Ai, Gadaleta, Emanuela, Rhys, Hefin I, Kennedy, Paul T, Hermida, Miguel A, Chang, Ting‐Yu, Shaw, Peter E, Reynolds, Louise E, McKay, Tristan R, Wang, Hsei‐Wei, Ribeiro, Paulo S, Plevin, Michael J, Lagos, Dimitris, Lemoine, Nicholas R, Rajan, Prabhakar, Graham, Trevor A, Chelala, Claude, Hodivala‐Dilke, Kairbaan M, Spendlove, Ian, Sharp, Tyson V
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079541/
https://ncbi.nlm.nih.gov/pubmed/29930174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708304
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