The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development

Loss of heterozygosity (LOH) and homozygous deletions at chromosome 3p21.3 are common in both small and nonsmall cell lung cancers, indicating the likely presence of tumor suppressor genes (TSGs). Although genetic and epigenetic changes within this region have been identified, the functional signifi...

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Bibliographische Detailangaben
Hauptverfasser: Sharp, Tyson V., Al-Attar, Ahmad, Foxler, Daniel E., Ding, Li, de A. Vallim, Thomas Q., Zhang, Yining, Nijmeh, Hala S., Webb, Thomas M., Nicholson, Andrew G., Zhang, Qunyuan, Kraja, Aldi, Spendlove, Ian, Osborne, John, Mardis, Elaine, Longmore, Gregory D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604919/
https://ncbi.nlm.nih.gov/pubmed/19060205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805003105
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