In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator

mGlu5 receptor-mediated polyphosphoinositide (PI) hydrolysis is classically measured by determining the amount of radioactivity incorporated in inositolmonophosphate (InsP) after labeling of membrane phospholipids with radioactive inositol. Although this method is historically linked to the study of...

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書目詳細資料
發表在:Front Pharmacol
Main Authors: Zuena, Anna R., Iacovelli, Luisa, Orlando, Rosamaria, Di Menna, Luisa, Casolini, Paola, Alemà, Giovanni Sebastiano, Di Cicco, Gabriele, Battaglia, Giuseppe, Nicoletti, Ferdinando
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079191/
https://ncbi.nlm.nih.gov/pubmed/30108503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00804
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