In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator

mGlu5 receptor-mediated polyphosphoinositide (PI) hydrolysis is classically measured by determining the amount of radioactivity incorporated in inositolmonophosphate (InsP) after labeling of membrane phospholipids with radioactive inositol. Although this method is historically linked to the study of...

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Vydáno v:Front Pharmacol
Hlavní autoři: Zuena, Anna R., Iacovelli, Luisa, Orlando, Rosamaria, Di Menna, Luisa, Casolini, Paola, Alemà, Giovanni Sebastiano, Di Cicco, Gabriele, Battaglia, Giuseppe, Nicoletti, Ferdinando
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079191/
https://ncbi.nlm.nih.gov/pubmed/30108503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00804
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