In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator

mGlu5 receptor-mediated polyphosphoinositide (PI) hydrolysis is classically measured by determining the amount of radioactivity incorporated in inositolmonophosphate (InsP) after labeling of membrane phospholipids with radioactive inositol. Although this method is historically linked to the study of...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Zuena, Anna R., Iacovelli, Luisa, Orlando, Rosamaria, Di Menna, Luisa, Casolini, Paola, Alemà, Giovanni Sebastiano, Di Cicco, Gabriele, Battaglia, Giuseppe, Nicoletti, Ferdinando
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079191/
https://ncbi.nlm.nih.gov/pubmed/30108503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00804
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