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Genetic and epigenetic influences on the loss of tolerance in autoimmunity

Immunological tolerance loss is fundamental to the development of autoimmunity; however, the underlying mechanisms remain elusive. Immune tolerance consists of central and peripheral tolerance. Central tolerance, which occurs in the thymus for T cells and bone marrow for B cells, is the primary way...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Zhang, Peng, Lu, Qianjin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079019/
https://ncbi.nlm.nih.gov/pubmed/29503444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2017.137
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