Tristetraprolin Overexpression in Gastric Cancer Cells Suppresses PD-L1 Expression and Inhibits Tumor Progression by Enhancing Antitumor Immunity

The RNA-binding protein tristetraprolin (TTP) binds to adenosine-uridine AU-rich elements in the 3′-untranslated region of messenger RNAs and facilitates rapid degradation of the target mRNAs. Therefore, it regulates the expression of multiple cancer and immunity-associated transcripts. Furthermore,...

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Udgivet i:Mol Cells
Main Authors: Guo, Jian, Qu, Huiheng, Shan, Ting, Chen, Yigang, Chen, Ye, Xia, Jiazeng
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society for Molecular and Cellular Biology 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078856/
https://ncbi.nlm.nih.gov/pubmed/29936792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2018.0040
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