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Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes

Certain dysregulated chondrocyte metabolic adaptive responses such as decreased activity of the master regulator of energy metabolism AMP-activated protein kinase (AMPK) promote osteoarthritis (OA). Metabolism intersects with epigenetic and transcriptional responses. Hence, we studied chondrocyte AT...

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Vydáno v:J Biol Chem
Hlavní autoři: Chen, Liang-Yu, Lotz, Martin, Terkeltaub, Robert, Liu-Bryan, Ru
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078460/
https://ncbi.nlm.nih.gov/pubmed/29929979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002261
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