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Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme

The biosynthesis of branched alkoxy groups, such as the unique t-butyl group found in a variety of natural products, is still poorly understood. Recently, cystobactamids were isolated and identified from Cystobacter sp as novel antibacterials. These metabolites contain an isopropyl group proposed to...

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Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Wang, Yuanyou, Schnell, Bastien, Baumann, Sascha, Müller, Rolf, Begley, Tadhg P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078419/
https://ncbi.nlm.nih.gov/pubmed/28040895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b10901
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