SMAD4 loss is associated with cetuximab resistance and induction of MAPK/JNK activation in head and neck cancer cells

PURPOSE: We previously demonstrated an association between decreased SMAD4 expression and cetuximab resistance in head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to further elucidate the clinical relevance of SMAD4 loss in HNSCC. EXPERIMENTAL DESIGN: SMAD4 expression was...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Ozawa, Hiroyuki, Ranaweera, Ruchira, Izumchenko, Evgeny, Makarev, Eugene, Zhavoronkov, Alex, Fertig, Elana J., Howard, Jason D., Markovic, Ana, Bedi, Atul, Ravi, Rajani, Perez, Jimena, Le, Quynh-Thu, Kong, Christina S., Jordan, Richard C., Wang, Hao, Kang, Hyunseok, Quon, Harry, Sidransky, David, Chung, Christine H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078415/
https://ncbi.nlm.nih.gov/pubmed/28522603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1686
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