SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis

Adult tongue epithelium is continuously renewed from epithelial progenitor cells, a process that requires hedgehog (HH) signaling. In mice, pharmacological inhibition of the HH pathway causes taste bud loss within a few weeks. Previously, we demonstrated that sonic hedgehog (SHH) overexpression in l...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Development
Main Authors: Castillo-Azofeifa, David, Seidel, Kerstin, Gross, Lauren, Golden, Erin J., Jacquez, Belkis, Klein, Ophir D., Barlow, Linda A.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2018
Teme:
Stem Cells and Regeneration
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078335/
https://ncbi.nlm.nih.gov/pubmed/29945863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.164889
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