Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid

The interaction between signaling pathways is a central question in the study of organogenesis. Using the developing murine tongue as a model, we uncovered unknown relationships between Sonic hedgehog (SHH) and retinoic acid (RA) signaling. Genetic loss of SHH signaling leads to enhanced RA activity...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: El Shahawy, Maha, Reibring, Claes-Göran, Neben, Cynthia L., Hallberg, Kristina, Marangoni, Pauline, Harfe, Brian D., Klein, Ophir D., Linde, Anders, Gritli-Linde, Amel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536368/
https://ncbi.nlm.nih.gov/pubmed/28715412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006914
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